Clinically Studied for Cardiovascular Health
Clinically Studied for Vascular Health. Support your cellular health with NOVOS Core, the award-winning, once-daily longevity drink.
Research on the 12 Hallmarks of Aging helped guide NOVOS Core’s ingredient selection. Its finished formula was studied in a randomized, double-blind, placebo-controlled human trial in healthy men and women aged 40+, which showed benefits to cardiovascular aging markers. Published in European Heart Journal Open (Oxford University Press), 2026. Individual results may vary.
All 12 longevity ingredients in one daily serving, including Calcium Alpha-Ketoglutarate, Fisetin, Pterostilbene, Glycine, Magnesium Malate, L-Theanine and Micro-dosed Lithium. No proprietary blends – every dose disclosed.
Mix one sachet into water once a day. Dissolves easily. Most customers take NOVOS Core in the morning, though some prefer the evening, since better sleep is one of the changes customers mention most. Consistency matters more than the time of day.
Free shipping on all subscriptions. Pause, skip, or cancel anytime from your account. HSA and FSA eligible.
Sugar-free, vegan, gluten-free. No artificial sweeteners. Manufactured in the USA in a cGMP facility and third-party tested.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
**Cardiovascular support is based on a six-month randomized, double-blind, placebo-controlled human trial that randomized 61 generally healthy men and women aged 40+, published in European Heart Journal Open (Oxford University Press), 2026. See the study details and limitations. Individual results may vary.
Verified customer reviews
“It’s definitely doing something.” Virginia G. “More energy and less fatigue.” Harriet B. “My skin looks firmer and healthier.” Chris H. “Waited so long for a product like yours.” Charlotte F. Verified customer reviews. Individual results may vary.
Research on the Hallmarks of Aging helped guide our ingredient selection.
Learn more about Healthy agingFormulated with hyaluronic acid, vitamin C and glycine.
Steadier, day-long energy. No caffeine, no crash.
Learn more about Better energy & recoveryFormulated with ingredients associated with restful sleep.
Learn more about Improved sleepRapid, durable support shown in a placebo-controlled human trial.
Learn more about Cardiovascular healthIn the trial, blood vessel function was measured after the first serving and after six months of daily use.
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In a randomized, double-blind, placebo-controlled trial in healthy men and women aged 40+, conducted at the University of Surrey, NOVOS Core showed benefits to cardiovascular function shortly after the very first dose.
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NOVOS Core includes Glycine, an amino acid studied in connection with falling asleep more easily and feeling more refreshed in the morning, and L-Theanine, studied in connection with calm, steady focus.
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Skin, focus, and an overall sense of well-being are the changes customers mention building over the first months.
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In a double-blind, placebo-controlled trial in healthy men and women aged 40+, NOVOS Core showed benefits to cardiovascular aging markers at six months: blood vessel flexibility, circulation, and blood pressure (for blood pressures already in the normal range).
Learn moreNOVOS Core’s finished formula was studied in a randomized, double-blind, placebo-controlled human trial that randomized 61 healthy men and women aged 40+.
Read the clinical trialCardiovascular · Randomized Human Trial
In a randomized, double-blind, placebo-controlled trial in healthy men and women aged 40+, NOVOS Core produced statistically significant improvements at six months in endothelial function, arterial flexibility, and systolic blood pressure (among participants already within the normal range).
Published in European Heart Journal Open (Oxford University Press), 2026. Learn moreIn a randomized, double-blind, placebo-controlled human trial, the complete NOVOS Core formulation showed statistically significant benefits to three cardiovascular markers (blood vessel function, arterial flexibility, and systolic blood pressure within the normal range).*
“This trial provides rare human evidence that a multi-pathway nutritional strategy can meaningfully influence cardiovascular aging biology itself.”
Flow-mediated dilation
How well your arteries open when your body needs more blood. In the trial, FMD improved 2.9 percentage points vs placebo — a leading marker of endothelial and vascular health.
Pulse wave velocity
How flexible your arteries are. PWV typically worsens about 1 m/s per decade; the trial showed a 1.18 m/s improvement vs placebo.
Systolic blood pressure
The pressure on your artery walls with every heartbeat. In the trial, systolic BP fell 6.1 mmHg vs placebo for blood pressure already in the normal range.
Member of / Selected for
Member of the Longevity Biotechnology Association and the Healthy Longevity Medicine Society; selected for the XPRIZE Healthspan Competition and the Wall Street Journal Future of Everything.
Randomized, double-blind, placebo-controlled human clinical research in healthy men and women 40+. Published in European Heart Journal Open (Oxford University Press), 2026. Read the clinical trial
No proprietary blends. Every dose printed on the label. Magnesium malate counts as one ingredient, listed here as magnesium and malate to match the Supplement Facts label. Patent pending.
NOVOS is built with guidance from scientists and physicians from Harvard Medical School and MIT, whose expertise spans aging biology, genomics, neurobiology, nutrition, and clinical medicine.
Scientific advisors: Dr. Pamela Maher (Salk Institute), Dr. J. Pedro Magalhães (Harvard Medical School), Dr. George Church (Harvard Medical School and MIT), Dr. Robert Lufkin (USC School of Medicine), Dr. Diogo Barardo (National University of Singapore), Dr. Oliver Medvedik (Cooper Union), and Dr. Avi Rosenbaum (scientist and biotech consultant).
“NOVOS takes a disciplined, biology-first approach in a space that too often prioritizes hype over evidence.”
Available at
NOVOS available at Mayo Clinic Store, Bumrungrad International Hospital, Erewhon, Equinox, Remedy Place, Four Seasons, and Sunlife Organics.
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The reason I first try the Novo's Core was desperation to reduce my CRP (C-reactive Protein). I used anti inflammatory powder before from my local Herbal store, and it was good. My CRP number was 8.5 and after 28 days of using the powder from the local store it brings down to 1.0. I stopped couple of months and it went back up again to 8.1. after searching I've found Novo's Core stating that it's anti inflammatory drink. I ordered, start taking it. I did some blood work fifteen days later and it come down to .9. I'm trying to find out what causes my body's inflammatory responses. I started Novo's Core 2023 on and off now it looks different from the old one. Maybe it is just the packaging. As a drink I blend with some fruits and it is delicious.
I'm 61 w/ chronic inflammation. Moving back to a colder climate moved me from less active to downright wanting to quit. I had to lean and hold on to railings, & the chronic pain in my hips, knees, hands & feet were making movement intolerable, so much so, I chose to sit more and more. In my quest for answers for anti-inflammatory care/cures, I stepped into the longevity world; something I balked at. After reading some testimonies on your product I decided to give them a try. I wish I had started them separately-but I took Core and Vital at the same time. On day 6, I got out of bed, and flew down the stairs…midway down I realized I didn't need to hold on to the rail. And I ran up the stairs to be sure…The pain was 80% gone! * there may be permanent damage from the years of inflammation. It has been 9 days. I am almost pain free. I ate badly one day and thought I'd pay for it. I didn't feel as good but wanted to see if this was just the improved food or the NOVOS. I am not going to "test" anymore. With NOVOS Core and Vital, I am not going to take this for granted. I am going to continue to improve my diet and exercise and see just how much healthier and stronger I can get! I am more focused, excited about life and my future. I am hoping more improvements will come. If they do, I'll be sure to let you know. So grateful for the brave scientists who work with integrity to help humans live the rich life God intended for His kids. God bless you!
Fantastic product and fantastic customer service! I highly recommend the NOVOS line. I've been taking them for 6 months and can see (skin) and feel (energy levels, sense well being) the difference. Also, I prefer the Orange flavored Core vs the unflavored version.
Amazing product. I have a very senstive Gut. I always bloated after eating or without eating any meal. When if i feel bloated i drink novos core it helps me a lot !! my Gut starts to digest better!! I feel my brain functions better because no more bloating!!!
I started taking Novo's Core in July 2022. I was 68 years old and my TruMe age was 69 years. I took the test again in September 2024 and my TruMe age had fallen to 62.2 years. I also take NMN (the ingredient in Novo's Boost) and other supplements, but Novos is the biggest change that I've made in that time. On the other hand my back and my shoulders are in much worse shape than they were in 2022.
After being without for a couple of days, I feel like it's time to reorder Core.
Individual experiences may vary and are distinct from results observed in controlled clinical research.
Everything you need to know about NOVOS, the science, and getting started.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.
Daily Organ Support Chews. Targeted nutrients to support essential organs including brain, eyes, liver, kidneys, and gut.
ShopSupport your cellular energy and recovery with NOVOS Boost, an ultra-pure NMN supplement. Take two capsules daily for 250 mg of NMN to support your body’s natural NAD+ production. Each bottle holds 60 capsules, a one-month supply. Vegan, sugar-free and gluten-free.
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